Polyphosphate modifies thefibrin network and down-regulatesfibrinolysis by attenuating binding of tPAand plasminogen tofibrin

Published: Jan 1, 2016
Abstract
Activated platelets secrete a negatively charged polymer, polyphosphate (polyP). Here, we explore the interactions of polyP with fibrin(ogen) and its effect on fibrin structure andfibrinolysis. Electrophoretic mobility and binding assays indicate that polyP interacts with fibrinogen and soluble fibrin. Clots formed in the presence of polyP exhibited reduced turbidity and permeability indicative of a tighter fibrin network, but these changes were...
Paper Details
Title
Polyphosphate modifies thefibrin network and down-regulatesfibrinolysis by attenuating binding of tPAand plasminogen tofibrin
Published Date
Jan 1, 2016
Journal
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