Euglycaemic glucose clamp: what it can and cannot do, and how to do it

The hyperinsulinaemic‐euglycaemic glucose clamp has always been regarded as the “gold standard” for the assessment of pharmacodynamic ( PD ) properties of insulin preparations; however, there has been controversy over a variety of methodogical details, such as study population, dosing time and the initial stabilization of blood glucose ( BG ) concentrations at the clamp target level, among clamp groups. As the impact of these details on PD...