Ions switch off darkness: role of TPC2 in melanosomes

Melanins are naturally occurring pigments that color the eye, skin, and hair of mammals, thereby protecting the body from harmful solar radiation that can lead to skin cancers. Melanins are synthesized and stored within specialized organelles called melanosomes, which are generated within epidermal and uveal melanocytes as well as retinal pigment epithelium. Packaging melanins into pigment granules relies on the proper localization and activity...