Match!

Physical Fitness in Adolescence and Subsequent Inflammatory Bowel Disease Risk

Published on Nov 5, 2015in Clinical and translational gastroenterology4.803
· DOI :10.1038/CTG.2015.49
Carren Melinder4
Estimated H-index: 4
(Örebro University),
Ayako Hiyoshi11
Estimated H-index: 11
(Örebro University)
+ 3 AuthorsScott M. Montgomery53
Estimated H-index: 53
(Örebro University)
Abstract
Objectives: Physical fitness may reduce systemic inflammation levels relevant to the risk of symptomatic Crohn's disease (CD) and ulcerative colitis (UC); we assessed if fitness in adolescence is a ...
  • References (38)
  • Citations (12)
📖 Papers frequently viewed together
20153.03Digestion
11 Authors (Peter Klare, ..., Wolfgang Huber)
37 Citations
201327.60BMJ
10 Authors (Hamed Khalili, ..., Andrew T. Chan)
60 Citations
62 Citations
78% of Scinapse members use related papers. After signing in, all features are FREE.
References38
Newest
#1Dirk Gevers (Broad Institute)H-Index: 70
#2Subra Kugathasan (Emory University)H-Index: 53
Last. Ramnik J. Xavier (Broad Institute)H-Index: 115
view all 32 authors...
Summary Inflammatory bowel diseases (IBDs), including Crohn's disease (CD), are genetically linked to host pathways that implicate an underlying role for aberrant immune responses to intestinal microbiota. However, patterns of gut microbiome dysbiosis in IBD patients are inconsistent among published studies. Using samples from multiple gastrointestinal locations collected prior to treatment in new-onset cases, we studied the microbiome in the largest pediatric CD cohort to date. An axis defined ...
1,274 CitationsSource
#1Daniel SjöbergH-Index: 8
#2Tommy HolmströmH-Index: 7
Last. Anders Rönnblom (Uppsala University)H-Index: 12
view all 7 authors...
Abstract Background and Aims: As a part of the Swedish ICURE study where the epidemiological results of ulcerative colitis and microscopic colitis recently have been published, we hereby present the corresponding figures for Crohn's disease. Methods: All patients diagnosed with Crohn's disease in Uppsala County (305,381 inhabitants) were prospectively registered during 2005–2006 and the same for all new patients with Crohn's disease in Uppsala Region (642,117 inhabitants) during 2007–2009. Resul...
72 CitationsSource
#1Joannie Ruel (ISMMS: Icahn School of Medicine at Mount Sinai)H-Index: 3
#2Darren Ruane (ISMMS: Icahn School of Medicine at Mount Sinai)H-Index: 11
Last. Jean-Frederic Colombel (ISMMS: Icahn School of Medicine at Mount Sinai)H-Index: 129
view all 5 authors...
IBD is a chronic disorder with disease onset ranging from early childhood to beyond the sixth decade of life. This Review provides an overview of the differences in epidemiology, clinical characteristics, and natural history of paediatric, adult, and elderly-onset IBD. In addition, potential differences in host–gene–microbial interactions according to age are highlighted.
102 CitationsSource
#1Hamed Khalili (Harvard University)H-Index: 28
#2Ashwin N. Ananthakrishnan (Harvard University)H-Index: 55
Last. Andrew T. Chan (Harvard University)H-Index: 81
view all 10 authors...
Objective To examine the association between physical activity and risk of ulcerative colitis and Crohn’s disease.
60 CitationsSource
#1Daniel SjöbergH-Index: 8
#2Tommy HolmströmH-Index: 7
Last. Anders Rönnblom (Uppsala University)H-Index: 12
view all 7 authors...
Abstract Background and aims The incidence of ulcerative colitis (UC) increased during the 20th century in Western Europe and the North America, but there are conflicting reports whether the incidence has declined, stabilized or continued to increase. The aim of this study was to evaluate the incidence of UC in the Uppsala Region, Sweden. Methods All new UC patients in Uppsala County (305,381 inhabitants) were prospectively registered during 2005–2006 and the same for all new UC patients in the ...
53 CitationsSource
#1Yaroslava Zhulina (Örebro University)H-Index: 10
#2Victoria Hahn-Strömberg (Örebro University)H-Index: 8
Last. Jonas Halfvarson (Örebro University)H-Index: 40
view all 12 authors...
Background: The mechanisms behind increased fecal calprotectin (FC) in healthy relatives of patients with inflammatory bowel disease (IBD) are unknown. Our aims were to explore if there is a subcli ...
18 CitationsSource
#1Tibor HlavatyH-Index: 16
#2Jozef TothH-Index: 7
Last. Martin HuorkaH-Index: 10
view all 7 authors...
BackgroundThe aetiology of inflammatory bowel disease (IBD) is not known but is likely to involve a combination of genetic predisposition and environmental risk factors. Smoking has been associated consistently with a higher risk of Crohn’s disease (CD), while appendectomy and smoking appear to diminish the risk of ulcerative colitis (UC). The roles of other environmental factors are unclear. The aim of the present study was to evaluate the association of CD and UC with several environmental ris...
26 CitationsSource
#1Simon S. M. Chan (UEA: University of East Anglia)H-Index: 13
#2Robert Luben (University of Cambridge)H-Index: 103
Last. Andrew Hart (UEA: University of East Anglia)H-Index: 33
view all 24 authors...
OBJECTIVES: Obesity is associated with a proinflammatory state that may be involved in the etiology of inflammatory bowel disease (IBD), for which there are plausible biological mechanisms. Our aim was to perform the first prospective cohort study investigating if there is an association between obesity and the development of incident IBD. METHODS: A total of 300,724 participants were recruited into the European Prospective Investigation into Cancer and Nutrition study. At recruitment, anthropom...
86 CitationsSource
#1Fredrik Toss (Umeå University)H-Index: 7
#2Anna Nordström (Umeå University)H-Index: 26
Last. Peter Nordström (Umeå University)H-Index: 40
view all 3 authors...
Background There is evidence that atherosclerosis begins in childhood. There is also evidence that inflammatory markers measured in middle and old age predict risks of cardiovascular disease. In th ...
14 CitationsSource
#1Luke Jostins (Wellcome Trust Sanger Institute)H-Index: 27
#2Stephan Ripke (Broad Institute)H-Index: 79
Last. Judy H. Cho (Yale University)H-Index: 61
view all 106 authors...
Crohn's disease and ulcerative colitis, the two common forms of inflammatory bowel disease (IBD), affect over 2.5 million people of European ancestry, with rising prevalence in other populations. Genome-wide association studies and subsequent meta-analyses of these two diseases as separate phenotypes have implicated previously unsuspected mechanisms, such as autophagy, in their pathogenesis and showed that some IBD loci are shared with other inflammatory diseases. Here we expand on the knowledge...
2,733 CitationsSource
Cited By12
Newest
#1Helen Tremlett (UBC: University of British Columbia)H-Index: 42
#2Ruth Ann Marrie (UM: University of Manitoba)H-Index: 51
A prodrome is considered an early set of signs or symptoms indicating the onset of a disease or illness. In multiple sclerosis (MS), the prodromal period is the months or years before our current, classic understanding of "MS symptom onset." Prodromal periods are well recognized in other neurodegenerative conditions and more recently have been shown in MS. In this Viewpoint, we reflect on the emerging evidence surrounding the MS prodrome, including features that may be common across chronic infl...
1 CitationsSource
#1Jan Bilski (Jagiellonian University Medical College)H-Index: 24
#2Agnieszka Irena Mazur-Bialy (Jagiellonian University Medical College)H-Index: 13
Last. T. BrzozowskiH-Index: 16
view all 11 authors...
Inflammatory bowel diseases (IBDs) are a group of disorders which include ulcerative colitis and Crohn’s disease. Obesity is becoming increasingly more common among patients with inflammatory bowel disease and plays a role in the development and course of the disease. This is especially true in the case of Crohn’s disease. The recent results indicate a special role of visceral adipose tissue and particularly mesenteric adipose tissue, also known as “creeping fat”, in pathomechanism, leading to i...
6 CitationsSource
#1Andrea Lemos Cabalzar (UFJF: Universidade Federal de Juiz de Fora)H-Index: 2
#2Felipe Meirelles de Azevedo (UFJF: Universidade Federal de Juiz de Fora)
Last. Júlio Maria Fonseca Chebli (UFJF: Universidade Federal de Juiz de Fora)H-Index: 6
view all 6 authors...
BACKGROUND: Physical activity in daily life and exercise capacity have not been assessed in patients with Crohn's disease to date. OBJECTIVE: To evaluate the physical activity in daily life, exercise capacity, quality of life, and prevalence of mood disorders in patients with moderate-to-severe Crohn's disease on infliximab-induced remission and the possible associations among variables. METHODS: A cross-sectional preliminary study was conducted. Twenty-six patients with Crohn's disease and 20 c...
Source
#1Jamal Rahmani (Shahid Beheshti University of Medical Sciences and Health Services)H-Index: 9
#2Hamed Kord-Varkaneh (Shahid Beheshti University of Medical Sciences and Health Services)H-Index: 6
Last. Kevan Jacobson (UBC: University of British Columbia)H-Index: 31
view all 8 authors...
: The relationship between body mass index (BMI) and risk of inflammatory bowel disease (IBD) is controversial. We performed a dose-response meta-analysis to investigate the association between BMI and risk of incident ulcerative colitis (UC) and Crohn's disease (CD) using prospective cohort studies. A systematic search was conducted in MEDLINE/PubMed, SCOPUS, Cochrane, and Web of Science databases from inception to January 2019. DerSimonian and Laird random-effects model was used to estimate co...
9 CitationsSource
#1Katharina EckertH-Index: 4
Last. Gerhard Huber (Heidelberg University)H-Index: 8
view all 4 authors...
Background Patients with Inflammatory Bowel Disease (IBD) also suffer from a wide range of additional disorders, which may be caused by the disease, the side effect of the medication, or a lack of physical activity (PA). This results in reduced physical and psychological wellbeing. However, as known from other chronic diseases exercise could be utilized as supportive therapy for IBD patients. Main goals of this article are (a) collecting data of the effects structured physical activity intervent...
3 CitationsSource
#1Jana G. Hashash (AUB: American University of Beirut)H-Index: 19
#2David G. Binion (University of Pittsburgh)H-Index: 46
: There is sparse information regarding exercise and inflammatory bowel disease (IBD). Furthermore, the importance of regular exercise in the optimal management of IBD has not received attention in guidelines and is often overlooked by practitioners. This article summarizes evidence regarding health benefits of exercise, guidelines regarding exercise in the general population and chronic inflammatory disorder populations, limitations regarding exercise capacity in patients with IBD, the associat...
4 CitationsSource
#1Carren Melinder (Örebro University)H-Index: 4
#2Ayako Hiyoshi (Örebro University)H-Index: 11
Last. Scott M. Montgomery (Örebro University)H-Index: 53
view all 5 authors...
OBJECTIVE: To determine if low psychosocial stress resilience in adolescence (increasing chronic stress arousal throughout life) is associated with an increased inflammatory bowel disease (IBD) ris ...
10 CitationsSource
#1Adam S. Cheifetz (BIDMC: Beth Israel Deaconess Medical Center)H-Index: 36
#2Robert Gianotti (BIDMC: Beth Israel Deaconess Medical Center)H-Index: 5
Last. Peter R. Gibson (Monash University)H-Index: 65
view all 4 authors...
Patients and physicians often have many questions regarding the role of complementary and alternative medicines (CAMs), or nonallopathic therapies, for inflammatory bowel diseases (IBDs). CAMs of various forms are used by more than half of patients with IBD during some point in their disease course. We summarize the available evidence for the most commonly used and discussed CAMs. We discuss evidence for the effects of herbs (such as cannabis and curcumin), probiotics, acupuncture, exercise, and...
50 CitationsSource
#1Christian MaaserH-Index: 31
#2Ebbe LangholzH-Index: 41
Last. Vito AnneseH-Index: 66
view all 15 authors...
: This ECCO Topical Review of the European Crohn's and Colitis Organisation [ECCO] focuses on the role of environmental factors with respect to the development of inflammatory bowel disease [IBD] as well as their influence on the course of established IBD. The objective was to reach expert consensus to provide evidence-based guidance for clinical practice.
13 CitationsSource
#1Qiang Wang (Nanjing Medical University)H-Index: 2
#2Ke-Qun Xu (Nanjing Medical University)H-Index: 2
Last. Xiao-Yong Wang (Nanjing Medical University)H-Index: 2
view all 6 authors...
Abstract Background Previous studies of an association between physical activity and inflammatory bowel disease have yielded conflicting results. Aim This meta-analysis was conducted to clarify whether there is an association between physical activity and inflammatory bowel disease. Methods The PubMed and Web of Science databases were searched for relevant studies published up to October 2015. Data were extracted and the summary relative risks (RRs) were calculated using a random effects or a fi...
12 CitationsSource