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Evaluation of off-target and on-target scoring algorithms and integration into the guide RNA selection tool CRISPOR

Published on Dec 1, 2016in Genome Biology14.03
· DOI :10.1186/s13059-016-1012-2
Maximilian Haeussler19
Estimated H-index: 19
(UCSC: University of California, Santa Cruz),
Kai Schönig21
Estimated H-index: 21
(Heidelberg University)
+ 9 AuthorsJean-Paul Concordet21
Estimated H-index: 21
(French Institute of Health and Medical Research)
Abstract
Background The success of the CRISPR/Cas9 genome editing technique depends on the choice of the guide RNA sequence, which is facilitated by various websites. Despite the importance and popularity of these algorithms, it is unclear to which extent their predictions are in agreement with actual measurements.
  • References (55)
  • Citations (234)
References55
Newest
#1Daesik Kim (SNU: Seoul National University)H-Index: 12
#2Sojung Kim (SNU: Seoul National University)H-Index: 10
Last.Jin-Soo Kim (SNU: Seoul National University)H-Index: 52
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#1Shashank Gandhi (NYU: New York University)H-Index: 4
#2Maximilian Haeussler (UCSC: University of California, Santa Cruz)H-Index: 19
Last.Alberto Stolfi (NYU: New York University)H-Index: 15
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#1Traver HartH-Index: 12
#2Megha Chandrashekhar (U of T: University of Toronto)H-Index: 5
Last.Jason Moffat (CIFAR: Canadian Institute for Advanced Research)H-Index: 41
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#1Nathan D. Wong (UW: University of Washington)H-Index: 80
#2Weijun Liu (WashU: Washington University in St. Louis)H-Index: 4
Last.Xiaowei Wang (WashU: Washington University in St. Louis)H-Index: 22
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#1Ritambhara Singh (UVA: University of Virginia)H-Index: 8
#2Cem Kuscu (UVA: University of Virginia)H-Index: 14
Last.Mazhar Adli (UVA: University of Virginia)H-Index: 25
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#2Juhua Zhang (BIT: Beijing Institute of Technology)H-Index: 1
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#2Pranit Mukherjee (ICAR: Indian Council of Agricultural Research)
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#1Hye-Kyung Lee (NIH: National Institutes of Health)H-Index: 13
#2Michaela Willi (NIH: National Institutes of Health)H-Index: 6
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#1Laurence O. W. Wilson (CSIRO: Commonwealth Scientific and Industrial Research Organisation)H-Index: 2
#2Sara Hetzel (FU: Free University of Berlin)
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#1Kathleen Keough (UCSF: University of California, San Francisco)
#2Svetlana Lyalina (UCSF: University of California, San Francisco)
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#1Daqi Wang (Fudan University)H-Index: 1
#2Cheng-Dong Zhang (Fudan University)
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View next paperGUIDE-seq enables genome-wide profiling of off-target cleavage by CRISPR-Cas nucleases.