Evaluation of off-target and on-target scoring algorithms and integration into the guide RNA selection tool CRISPOR.

Volume: 17, Issue: 1, Pages: 148 - 148
Published: Jul 5, 2016
Abstract
The success of the CRISPR/Cas9 genome editing technique depends on the choice of the guide RNA sequence, which is facilitated by various websites. Despite the importance and popularity of these algorithms, it is unclear to which extent their predictions are in agreement with actual measurements. We conduct the first independent evaluation of CRISPR/Cas9 predictions. To this end, we collect data from eight SpCas9 off-target studies and compare...
Paper Details
Title
Evaluation of off-target and on-target scoring algorithms and integration into the guide RNA selection tool CRISPOR.
Published Date
Jul 5, 2016
Volume
17
Issue
1
Pages
148 - 148
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