Chimeric antigen receptors: driving immunology towards synthetic biology
Abstract
The advent of second generation chimeric antigen receptors and the CD19 paradigm have ushered a new therapeutic modality in oncology. In contrast to earlier forms of adoptive cell therapy, which were based on the isolation and expansion of naturally occurring T cells, CAR therapy is based on the design and manufacture of engineered T cells with optimized properties. A new armamentarium, comprising not only CARs but also chimeric costimulatory...
Paper Details
Title
Chimeric antigen receptors: driving immunology towards synthetic biology
Published Date
Aug 1, 2016
Volume
41
Pages
68 - 76
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