The Biochemical and Cellular Basis of Cell Proliferation Assays That Use Tetrazolium Salts

Published: Jan 1, 1996
Abstract
The MTT assay is widely used in cell proliferation and cytotoxicity assays. Most cellular bioreduction of MTT is associated with enzymes of the endoplasmic reticulum and involves the reduced pyridine nucleotides NADH and, to a lesser extent, NADPH. Succinate is a weak electron donor for mitochondrial MTT reduction. Recently, new tetrazolium salt assays that use intermediate electron acceptors to facilitate reduction have been introduced. In this...
Paper Details
Title
The Biochemical and Cellular Basis of Cell Proliferation Assays That Use Tetrazolium Salts
Published Date
Jan 1, 1996
Journal
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