Original paper

Distinct role of heme oxygenase-1 in early- and late-stage intracerebral hemorrhage in 12-month-old mice

Volume: 37, Issue: 1, Pages: 25 - 38
Published: Jul 20, 2016
Abstract
Intracerebral hemorrhage (ICH) is a devastating form of stroke with high morbidity and mortality. Heme oxygenase-1 (HO-1), the key enzyme in heme degradation, is highly expressed after ICH, but its role is still unclear. In this study, we used an HO-1 inducer and inhibitor to test the role of HO-1 in different stages of ICH in vivo and in vitro. In the early stage of ICH, high HO-1 expression worsened the outcomes of mice subjected to the...
Paper Details
Title
Distinct role of heme oxygenase-1 in early- and late-stage intracerebral hemorrhage in 12-month-old mice
Published Date
Jul 20, 2016
Volume
37
Issue
1
Pages
25 - 38
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