Acylase‐containing polyurethane coatings with anti‐biofilm activity

Due to the prevalence of biofilm‐related infections, which are mediated by bacterial quorum sensing, there is a critical need for materials and coatings that resist biofilm formation. We have developed novel anti‐biofilm coatings that disrupt quorum sensing in surface‐associated bacteria via the immobilization of acylase in polyurethane films. Specifically, acylase from Aspergillus melleus was covalently immobilized in biomedical grade...