The role of mitochondrial DNA damage in the development of atherosclerosis
Abstract
Mitochondria are the cellular powerhouses, fuelling metabolic processes through their generation of ATP. However we now recognise that these organelles also have pivotal roles in producing reactive oxygen species (ROS) and in regulating cell death, inflammation and metabolism. Mitochondrial dysfunction therefore leads to oxidative stress, cell death, metabolic dysfunction and inflammation, which can all promote atherosclerosis. Recent evidence...
Paper Details
Title
The role of mitochondrial DNA damage in the development of atherosclerosis
Published Date
Nov 1, 2016
Volume
100
Pages
223 - 230
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