The accuracy of cell‐free fetal DNA‐based non‐invasive prenatal testing in singleton pregnancies: a systematic review and bivariate meta‐analysis

Cell-free fetal DNA (cffDNA) non-invasive prenatal testing (NIPT) is rapidly expanding, and is being introduced at varying rates depending on country and condition.Determine accuracy of cffDNA-based NIPT for all conditions. Evaluate influence of other factors on test performance.Medline, Embase, CINAHL, Cochrane Library, from 1997 to April 2015.Cohort studies reporting cffDNA-based NIPT performance in singleton pregnancies.Bivariate or...