Os2–Os4 Switch Controls DNA Knotting and Anticancer Activity
Abstract
Dinuclear trihydroxido-bridged osmium–arene complexes are inert and biologically inactive, but we show here that linking dihydroxido-bridged OsII–arene fragments by a bridging di-imine to form a metallacycle framework results in strong antiproliferative activity towards cancer cells and distinctive knotting of DNA. The shortened spacer length reduces biological activity and stability in solution towards decomposition to biologically inactive...
Paper Details
Title
Os2–Os4 Switch Controls DNA Knotting and Anticancer Activity
Published Date
Jul 25, 2016
Journal
Volume
55
Issue
31
Pages
8909 - 8912
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