Emerging roles of pro-resolving lipid mediators in immunological and adaptive responses to exercise-induced muscle injury.

Lipid mediators are bioactive metabolites of the essential polyunsaturated fatty acids (PUFA) that play diverse roles inthe initiation, self-limitation, and active resolution of inflammation. Prostaglandins, classical pro-inflammatory lipid metabolites of arachidonic acid, have long been implicated in immunological and adaptive muscle responses to acute injury and exercise-induced stress. More recently, PUFA metabolites have been discovered...