Review paper
A second chance for telomerase reverse transcriptase in anticancer immunotherapy
Abstract
Telomerase reverse transcriptase (TERT) is a self-antigen that is expressed constitutively in many tumours, and is, therefore, an important target for anticancer immunotherapy. In the past 10 years, trials of immunotherapy with TERT-based vaccines have demonstrated only modest benefits. In this Perspectives, I discuss the possible immunological reasons for this limited antitumour efficacy, and propose that advances in our understanding of the...
Paper Details
Title
A second chance for telomerase reverse transcriptase in anticancer immunotherapy
Published Date
Jun 1, 2016
Volume
14
Issue
2
Pages
115 - 128
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