APOBEC3DE Antagonizes Hepatitis B Virus Restriction Factors APOBEC3F and APOBEC3G

The APOBEC3 locus consists of seven genes (A3A–A3C, A3DE, A3F–A3H) that encode DNA cytidine deaminases. These enzymes deaminate single-stranded DNA, the result being DNA peppered with CG → TA mutations preferentially in the context of 5′TpC with the exception of APOBEC3G (A3G), which prefers 5′CpC dinucleotides. Hepatitis B virus (HBV) DNA is vulnerable to genetic editing by APOBEC3 cytidine deaminases, A3G being a major restriction factor....