Mitochondrial Dynamics Controls T Cell Fate through Metabolic Programming
Abstract
Activated effector T (TE) cells augment anabolic pathways of metabolism, such as aerobic glycolysis, while memory T (TM) cells engage catabolic pathways, like fatty acid oxidation (FAO). However, signals that drive these differences remain unclear. Mitochondria are metabolic organelles that actively transform their ultrastructure. Therefore, we questioned whether mitochondrial dynamics controls T cell metabolism. We show that TE cells have...
Paper Details
Title
Mitochondrial Dynamics Controls T Cell Fate through Metabolic Programming
Published Date
Jun 1, 2016
Journal
Volume
166
Issue
1
Pages
63 - 76
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