Imaging mass spectrometry for accessing molecular changes during burn wound healing

The spatiotemporal analysis of the proteomic profile during human wound healing is a critical investigative step that can establish the complex interplay of molecular events that comprise the local response to burn injury. Partial‐thickness wound samples with adjacent “normal” skin were collected from twenty‐one patients with burn wounds and examined across a time spectrum ranging from the acute injury period at 3, 6, 11 days to the later...