Microglial immunophenotype in dementia with Alzheimer’s pathology

Genetic risk factors for Alzheimer’s disease imply that inflammation plays a causal role in development of the disease. Experimental studies suggest that microglia, as the brain macrophages, have diverse functions, with their main role in health being to survey the brain parenchyma through highly motile processes. Using the Medical Research Council Cognitive Function and Ageing Studies resources, we have immunophenotyped microglia to investigate...