The effects of graded levels of calorie restriction: VII. Topological rearrangement of hypothalamic aging networks
Abstract
Connectivity in a gene-gene network declines with age, typically within gene clusters. We explored the effect of short-term (3 months) graded calorie restriction (CR) (up to 40 %) on network structure of aging-associated genes in the murine hypothalamus by using conditional mutual information. The networks showed a topological rearrangement when exposed to graded CR with a higher relative within cluster connectivity at 40CR. We observed changes...
Paper Details
Title
The effects of graded levels of calorie restriction: VII. Topological rearrangement of hypothalamic aging networks
Published Date
Apr 23, 2016
Journal
Volume
8
Issue
5
Pages
917 - 932
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