Match!

Low-level prenatal lead exposure and infant sensory function.

Published on Dec 1, 2016in Environmental Health4.43
路 DOI :10.1186/s12940-016-0148-6
Monica K. Silver7
Estimated H-index: 7
(UM: University of Michigan),
Xiaoqing Li1
Estimated H-index: 1
(PKU: Peking University)
+ 7 AuthorsBetsy Lozoff45
Estimated H-index: 45
(UM: University of Michigan)
Abstract
Background Lead is a pervasive neurotoxicant that has been associated with poorer cognitive, behavioral, and motor outcomes in children. The effects of lead on sensory function have not been well characterized. The aim of this study was to assess the effects of prenatal lead exposure on infant sensory function, as measured by auditory brainstem response (ABR) and grating visual acuity (VA).
  • References (51)
  • Citations (7)
馃摉 Papers frequently viewed together
20172.78PLOS ONE
12 Citations
9 Citations
78% of Scinapse members use related papers. After signing in, all features are FREE.
References51
Newest
#2Thais C. MorataH-Index: 24
view all 5 authors...
3 CitationsSource
#1K谩tia de Freitas Alvarenga (USP: University of S茫o Paulo)H-Index: 13
#2Thais C. Morata (NIOSH: National Institute for Occupational Safety and Health)H-Index: 24
Last. Lilian Cassia Bornia Jacob Corteletti (USP: University of S茫o Paulo)H-Index: 4
view all 5 authors...
Introduction: Earlier studies have demonstrated an auditory effect of lead exposure in children, but information on the effects of low chronic exposures needs to be further elucidated. Objective: To investigate the effect of low chronic exposures of the auditory system in children with a history of low blood lead levels, using an auditory electrophysiological test. Methods: Contemporary cross-sectional cohort. Study participants underwent tympanometry, pure tone and speech audiometry, transient ...
4 CitationsSource
#1Jian鈥檃n Liu (SYSU: Sun Yat-sen University)H-Index: 2
#2Dingguo Gao (SYSU: Sun Yat-sen University)H-Index: 2
Last. Yajun Chen (SYSU: Sun Yat-sen University)H-Index: 12
view all 6 authors...
Abstract Purpose Our pilot studies showed that there was a significant relationship between blood lead levels of women at the first trimester and scores of neonatal behavioral neurological assessment (NBNA). This study went further (1) to determine particular neurotoxicity during a specific trimester, (2) to analyze 鈥渟afe鈥 levels of Pb in neonates, and (3) to identify influencing factors for prenatal Pb exposure. Method A total of 415 mothers with newborn located Shenzhen, Guangdong, China parti...
33 CitationsSource
#1Zhu Chen (Johns Hopkins University)H-Index: 9
#2Robert A. MyersH-Index: 1
Last. Xiao Wang (Johns Hopkins University)H-Index: 52
view all 15 authors...
Placental transfer and concentrations of cadmium, mercury, lead, and selenium in mothers, newborns, and young children
56 CitationsSource
#1Nagendra Kumar Rai (CSIR: Council of Scientific and Industrial Research)H-Index: 4
#2Anushruti Ashok (CSIR: Council of Scientific and Industrial Research)H-Index: 3
Last. Sanghamitra Bandyopadhyay (CSIR: Council of Scientific and Industrial Research)H-Index: 22
view all 7 authors...
Abstract Arsenic (As), lead (Pb) and cadmium (Cd) are the major metal contaminants of ground water in India. We have reported the toxic effect of their mixture (metal mixture, MM), at human relevant doses, on developing rat astrocytes. Astrocyte damage has been shown to be associated with myelin disintegration in CNS. We, therefore, hypothesized that the MM would perturb myelinating white matter in cerebral cortex, optic nerve (O.N.) and retina. We observed modulation in the levels of myelin and...
39 CitationsSource
#1Weerasak Chonchaiya (UM: University of Michigan)H-Index: 1
#2Twila Tardif (UM: University of Michigan)H-Index: 25
Last. Betsy Lozoff (UM: University of Michigan)H-Index: 45
view all 9 authors...
Auditory processing capabilities at the subcortical level have been hypothesized to impact an individual鈥檚 development of both language and reading abilities. The present study examined whether auditory processing capabilities relate to language development in healthy 9-month-old infants. Participants were 71 infants (31 boys and 40 girls) with both Auditory Brainstem Response (ABR) and language assessments. At 6 weeks and/or 9 months of age, the infants underwent ABR testing using both a standa...
18 CitationsSource
#1S. Allen Counter (Harvard University)H-Index: 19
#2Leo H. Buchanan (Harvard University)H-Index: 21
Last. Fernando Ortega (USFQ: Universidad San Francisco de Quito)H-Index: 19
view all 3 authors...
Objectives Decreased blood hemoglobin (HbB) levels and anemia have been associated with abnormal brainstem auditory evoked responses (BAER). Lead (Pb) exposure has also been associated with anemia and aberrant BAER. This study investigated the relationship between HbB level and BAER wave latency and amplitude in Pb-exposed Andean children.
9 CitationsSource
#1Hassan Imran Afridi (DCU: Dublin City University)H-Index: 21
#2Tasneem Gul Kazi (University of Sindh)H-Index: 46
Last. Sirajuddin (University of Sindh)H-Index: 20
view all 13 authors...
The most common cause of blindness in developing countries is vitamin A deficiency. The World Health Organization estimates 13.8 million children to have some degree of visual loss related to vitamin A deficiency. The causes of night blindness in children are multifactorial, and particular consideration has been given to childhood nutritional deficiency, which is the most common problem found in underdeveloped countries. Such deficiency can result in physiological and pathological processes that...
11 CitationsSource
#1Hassan Imran Afridi (DCU: Dublin City University)H-Index: 21
#2Tasneem Gul Kazi (University of Sindh)H-Index: 46
Last. Mohammad Balal Arain (University of Sindh)H-Index: 21
view all 13 authors...
The causes of night blindness in children are multifactorial, and particular consideration has been given to childhood trace metals toxicity, which is the most common problem found in underdeveloped countries. This study was designed to compare the levels of cadmium (Cd), lead (Pb), and nickel (Ni) in scalp hair, blood, and urine of night blindness children age ranged 3鈥7 and 8鈥12 years of both genders, comparing them to sex- and age-matched controls. A microwave-assisted wet acid digestion proc...
15 CitationsSource
#1S.A. Counter (Harvard University)H-Index: 6
#2Leo H. Buchanan (Harvard University)H-Index: 21
Last. Erik BorgH-Index: 1
view all 5 authors...
Abstract The purpose of this study was to investigate the neurological integrity and physiological status of the auditory brainstem tracts and nuclei in children with chronic lead (Pb) exposure using non-invasive acoustic stapedius reflex (ASR) measurements of afferent and efferent-neuromuscular auditory function. Following audiological examinations, uncrossed (ipsilateral) and crossed (contralateral) brainstem ASR responses were evoked by pure tone (500, 1000, and 2000聽Hz), and broadband noise ...
8 CitationsSource
Cited By7
Newest
#1Maryam Ebrahimi (TMU: Tarbiat Modares University)
#2Neda Khalili (Tehran University of Medical Sciences)H-Index: 1
Last. Nima Rezaei (Tehran University of Medical Sciences)H-Index: 49
view all 6 authors...
In our daily life, we are surrounded by harmful pollutants, including heavy metals that are not visible in the macroscopic view easily. Heavy metals can disrupt different aspects of human health, such as the immune system which has gained a lot of attention in recent decades. This had led to its rapid progression and new insights into its alterations in different diseases especially cancer. Heavy metals are non-biodegradable materials that exist in different parts of the food cycle, such as frui...
Source
#1Pahriya Ashrap (UM: University of Michigan)H-Index: 1
#2Deborah J. Watkins (UM: University of Michigan)H-Index: 14
Last. John D. Meeker (UM: University of Michigan)H-Index: 54
view all 10 authors...
Abstract Given the potential adverse health effects related to toxic trace metal exposure and insufficient or excessive levels of essential trace metals in pregnant women and their fetuses, the present study characterizes biomarkers of metal and metalloid exposure at repeated time points during pregnancy among women in Puerto Rico. We recruited 1040 pregnant women from prenatal clinics and collected urine, blood, and questionnaire data on demographics, product use, food consumption, and water us...
1 CitationsSource
#1Xia Liu (ECNU: East China Normal University)H-Index: 1
#2Fanfan Wei (ECNU: East China Normal University)H-Index: 1
Last. Xiaoming Zhou (ECNU: East China Normal University)H-Index: 20
view all 14 authors...
1 CitationsSource
#1Haoxing Cai (STU: Shantou University)H-Index: 1
#2Xijin Xu (STU: Shantou University)H-Index: 26
Last. Xia Huo (JNU: Jinan University)H-Index: 3
view all 6 authors...
Abstract Exposure to lead is associated with adverse effects on neurodevelopment. However, studies of the effects of lead on sensory integration are few. The purpose of this research is to investigate the effect of lead exposure on child sensory integration by correlating the blood lead levels of children with sensory processing measures. A total of 574 children, from 3 to 6 years of age, 358 from an electronic waste (e-waste) recycling town named Guiyu, and 216 from Haojiang, a nearby town with...
1 CitationsSource
#1Monica K. Silver (UM: University of Michigan)H-Index: 7
#2Aubrey L. Arain (UM: University of Michigan)H-Index: 1
Last. John D. Meeker (UM: University of Michigan)H-Index: 54
view all 7 authors...
Abstract Early-life exposure to heavy metals and/or trace metal imbalances can have negative developmental effects. Here we sought to characterize exposure profiles for 20 heavy metals and trace elements in umbilical cord blood plasma and identify demographic predictors of exposure. Twenty metals were measured in cord plasma from 357 Chinese infants using ICP-MS. Relationships between demographic variables and metals were analyzed using generalized linear models and logistic regression. Ten meta...
2 CitationsSource
#1Prattana Lopin (NU: Naresuan University)H-Index: 1
#2Kyle V. Lopin (NU: Naresuan University)H-Index: 1
In this paper we demonstrate a potentiostat built with a single commercially available integrated circuit (IC) that does not require any external electronic components to perform electrochemical experiments. This is done using the capabilities of the Programmable System on a Chip (PSoC庐) by Cypress Semiconductor, which integrates all of the necessary electrical components. This is in contrast to other recent papers that have developed potentiostats but require technical skills or specialized equ...
4 CitationsSource
#1Monica K. Silver (UM: University of Michigan)H-Index: 7
#2Jie Shao (ZJU: Zhejiang University)H-Index: 11
Last. John D. Meeker (UM: University of Michigan)H-Index: 54
view all 11 authors...
Abstract Background Occupational studies suggest that exposure to organophosphate insecticides (OPs) can lead to vision or hearing loss. Yet the effects of early-life exposure on visual and auditory function are unknown. Here we examined associations between prenatal OP exposure and grating visual acuity (VA) and auditory brainstem response (ABR) during infancy. Methods 30 OPs were measured in umbilical cord blood using gas chromatography tandem mass spectrometry in a cohort of Chinese infants. ...
5 CitationsSource
#1Margaret Carrel (UI: University of Iowa)H-Index: 12
#2David Zahrieh (UI: University of Iowa)H-Index: 1
Last. Audrey F. Saftlas (UI: University of Iowa)H-Index: 23
view all 8 authors...
Lead in maternal blood can cross the placenta and result in elevated blood lead levels in newborns, potentially producing negative effects on neurocognitive function, particularly if combined with childhood lead exposure. Little research exists, however, into the burden of elevated blood lead levels in newborns, or the places and populations in which elevated lead levels are observed in newborns, particularly in rural settings. Using ~2300 dried bloods spots collected within 1鈥3 days of birth am...
7 CitationsSource
#1Leilei Zhou (SJTU: Shanghai Jiao Tong University)H-Index: 2
#2Jian Xu (SJTU: Shanghai Jiao Tong University)H-Index: 11
Last. Wenjing Hu (SJTU: Shanghai Jiao Tong University)H-Index: 2
view all 7 authors...
Abstract Objective To evaluate the effects of maternal lead exposure during pregnancy on toddler cognitive development and the potential effect modification by maternal stress. Methods We conducted a prospective birth-cohort study in Shanghai from 2010 to 2012 and investigated 225 mother-infant pairs. The mothers were recruited in mid-to-late pregnancy and children were followed up until 24鈥36 months old. A self-administered Symptom Checklist-90-Revised Scale (SCL-90-R) was used to assess matern...
3 CitationsSource