Ubiquitin-specific protease 22 is a deubiquitinase of CCNB1
Abstract
The elevated level of CCNB1 indicates more aggressive cancer and poor prognosis. However, the factors that cause CCNB1 upregulation remain enigmatic. Herein, we identify USP22 as a CCNB1 interactor and discover that both USP22 and CCNB1 are dramatically elevated with a strong positive correlation in colon cancer tissues. USP22 stabilizes CCNB1 by antagonizing proteasome-mediated degradation in a cell cycle-specific manner. Phosphorylation of...
Paper Details
Title
Ubiquitin-specific protease 22 is a deubiquitinase of CCNB1
Published Date
Oct 13, 2015
Journal
Volume
1
Issue
1
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