Daisy-chain gene drives for the alteration of local populations

Abstract
RNA-guided gene drive elements could address many ecological problems by altering the traits of wild organisms, but the likelihood of global spread tremendously complicates ethical development and use. Here we detail a localized form of CRISPR-based gene drive composed of genetic elements arranged in a daisy-chain such that each element drives the next. “Daisy drive” systems can duplicate any effect achievable using an equivalent global drive...
Paper Details
Title
Daisy-chain gene drives for the alteration of local populations
Published Date
Jun 7, 2016
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