TIMP3 Modulates GHR Abundance and GH Sensitivity
Abstract
GH receptor (GHR) binds GH at the cell surface via its extracellular domain and initiates intracellular signal transduction, resulting in important anabolic and metabolic actions. GH signaling is subject to dynamic regulation, which in part is exerted by modulation of cell surface GHR levels. Constitutive and inducible metalloprotease-mediated cleavage of GHR regulate GHR abundance and thereby modulate GH action. We previously demonstrated that...
Paper Details
Title
TIMP3 Modulates GHR Abundance and GH Sensitivity
Published Date
Jun 1, 2016
Journal
Volume
30
Issue
6
Pages
587 - 599
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History