Pediatric cancer gone viral. Part I: strategies for utilizing oncolytic herpes simplex virus-1 in children

From the preceding, it is clear that oHSVs are safe in adults as agents for the treatment of cancer by a variety of delivery routes and offer several advantages. This is a large DNA virus that does not integrate into the host genome and a substantial amount of its DNA is not essential for the infection of and replication in tumor cells. This offers the potential for foreign therapeutic gene delivery to tumor cells to facilitate its efficacy by...