The “Sins” of the Fathers: Self-Healing Squamous Epithelioma in Scotland

Background: A review is presented of the recent progress made in mapping of the hereditary skin disease “Ferguson-Smith multiple self-healing squamous epithelioma.” Methods: The use of founder effects in an autosomal dominant disease is reviewed as applied to gene mapping efforts. Results: A common haplotype among Scottish families segregating Ferguson-Smith disease allowed the narrowing of the candidate gene interval and the identification of...