Verapamil-Sensitive Transport of Quinacrine and Methylene Blue via thePlasmodium falciparumChloroquine Resistance Transporter Reduces the Parasite's Susceptibility to these Tricyclic Drugs

Volume: 213, Issue: 5, Pages: 800 - 810
Published: Oct 26, 2015
Abstract
It is becoming increasingly apparent that certain mutations in the Plasmodium falciparum chloroquine resistance transporter (PfCRT) alter the parasite's susceptibility to diverse compounds. Here we investigated the interaction of PfCRT with 3 tricyclic compounds that have been used to treat malaria (quinacrine [QC] and methylene blue [MB]) or to study P. falciparum (acridine orange [AO]).We measured the antiplasmodial activities of QC, MB, and...
Paper Details
Title
Verapamil-Sensitive Transport of Quinacrine and Methylene Blue via thePlasmodium falciparumChloroquine Resistance Transporter Reduces the Parasite's Susceptibility to these Tricyclic Drugs
Published Date
Oct 26, 2015
Volume
213
Issue
5
Pages
800 - 810
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