DNA Polymerase θ: A Unique Multifunctional End-Joining Machine
Abstract
The gene encoding DNA polymerase θ (Polθ) was discovered over ten years ago as having a role in suppressing genome instability in mammalian cells. Studies have now clearly documented an essential function for this unique A-family polymerase in the double-strand break (DSB) repair pathway alternative end-joining (alt-EJ), also known as microhomology-mediated end-joining (MMEJ), in metazoans. Biochemical and cellular studies show that Polθ...
Paper Details
Title
DNA Polymerase θ: A Unique Multifunctional End-Joining Machine
Published Date
Sep 21, 2016
Journal
Volume
7
Issue
9
Pages
67 - 67
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