Genome-wide analysis reveals specificities of Cpf1 endonucleases in human cells
Abstract
Programmable clustered regularly interspaced short palindromic repeats (CRISPR) Cpf1 endonucleases are single-RNA-guided (crRNA) enzymes that recognize thymidine-rich protospacer-adjacent motif (PAM) sequences and produce cohesive double-stranded breaks (DSBs). Genome editing with CRISPR-Cpf1 endonucleases could provide an alternative to CRISPR-Cas9 endonucleases, but the determinants of targeting specificity are not well understood. Using...
Paper Details
Title
Genome-wide analysis reveals specificities of Cpf1 endonucleases in human cells
Published Date
Jun 6, 2016
Journal
Volume
34
Issue
8
Pages
863 - 868
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