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Recenti vedute sulla patogenesi degli stati protrombotici associati a ipercolesterolemia

Published on Mar 1, 2004in Recenti progressi in medicina
Patrizia Ferroni32
Estimated H-index: 32
,
Stefania Basili42
Estimated H-index: 42
(Sapienza University of Rome),
Giovanni Davì47
Estimated H-index: 47
Abstract
Hypercholesterolemia and overt atherosclerotic disorders have been associated with a low-grade inflammation that involves not only the intrinsic cells of the artery wall, but also circulating cells. Platelets as well as monocytes participate importantly in this disease process through the release of a wide variety of biologically active substances. Recent findings on the inflammatory actions of platelets have opened new perspectives in the comprehension of the pathogenetic mechanism(s) of atherosclerosis. Stimulated platelets, in fact, actively synthesize proinflammatory cytokines which have been all involved in the inflammatory process associated to hypercholesterolemia and plaque development. In this context, increasing evidence suggests that interrelated inhibition of inflammation and thrombosis induced by statins could largely contribute to clinical benefits from lipid-lowering therapy.
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K.G. Nevin1
Estimated H-index: 1
(UoK: University of Kerala),
T. Rajamohan1
Estimated H-index: 1
(UoK: University of Kerala)
Summary Background aims Experimental and epidemiological studies indicate an association between dietary saturated fatty acids and thrombosis, but the effects of individual fatty acids on haemostasis are still controversial. The purpose of this research is to evaluate the effect of feeding virgin coconut oil (VCO) on blood coagulation factors, lipid levels and in vitro oxidation of LDL in comparison with copra oil (CO) and sunflower oil (SFO) in cholesterol (1%) and oil (10% w/w) fed rats. Metho...