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Ischemia–Reperfusion Injury in Reconstructive Transplantation: An Undefined Conundrum

Published on Jan 1, 2015
· DOI :10.1007/978-1-4939-2071-6_22
Jerzy W. Kupiec-Weglinski57
Estimated H-index: 57
(UCLA: University of California, Los Angeles),
Kodi Azari6
Estimated H-index: 6
(UCLA: University of California, Los Angeles)
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Abstract
Ischemia–reperfusion injury (IRI), a major complication of organ transplantation, tissue resection, and hemorrhagic shock, is a dynamic process that involves two interrelated phases of local ischemic insult and inflammation-mediated reperfusion injury. This chapter highlights recent mechanistic insights into innate–adaptive immune cross talk and cell activation cascades leading to inflammation-mediated damage in IR-stressed tissues, and considers their pathophysiological relevance in the emerging field of vascularized composite allotransplantation (VCA). The interlocked molecular signaling pathways in histologically divergent cell types, the IRI kinetics, and positive versus negative regulatory loops at the innate–adaptive immune interface are discussed. Current gaps in our knowledge and mechanistic aspects necessitating basic and translational research are stressed. Improved appreciation of cellular and molecular events, which trigger and sustain local inflammation responses in experimental models, are fundamental to developing innovative strategies for treating VCAs suffering from IR-inflammation/dysfunction following prolonged periods of ex vivo storage. Achieving these goals should pave the road to improving the clinical outcomes and possibly achieving the ultimate goal of imposing operational immune tolerance in transplant patients.
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Published on Jul 1, 2013in Hepatology 14.97
Naoko Kamo6
Estimated H-index: 6
(UCLA: University of California, Los Angeles),
Bibo Ke33
Estimated H-index: 33
(UCLA: University of California, Los Angeles)
+ 4 AuthorsJerzy W. Kupiec-Weglinski57
Estimated H-index: 57
(UCLA: University of California, Los Angeles)
Apoptosis-associated speck-like protein containing a caspase recruitment domain (ASC), an adaptor protein for inflammasome receptors, is essential for inducing caspase-1 activation and the consequent secretion of interleukin-1β (IL-1β), which is associated with local inflammation during liver ischemia/reperfusion injury (IRI). However, little is known about the mechanisms by which the ASC/caspase-1/IL-1β axis exerts its function in hepatic IRI. This study was designed to explore the functional r...
82 Citations Source Cite
Published on May 1, 2013in Clinical Transplantation 1.67
J. Rodrigo Diaz-Siso6
Estimated H-index: 6
(Brigham and Women's Hospital),
Ericka M. Bueno18
Estimated H-index: 18
(Brigham and Women's Hospital)
+ 3 AuthorsStefan G. Tullius44
Estimated H-index: 44
(Brigham and Women's Hospital)
Vascularized composite tissue allotransplantation is a viable treatment option for injuries and defects that involve multiple layers of functional tissue. In the past 15 yr, more than 150 vascularized composite allotransplantation (VCA) surgeries have been reported for various anatomic locations including – but not limited to – trachea, larynx, abdominal wall, face, and upper and lower extremities. VCA can achieve a level of esthetic and functional restoration that is currently unattainable usin...
40 Citations Source Cite
Published on Feb 1, 2013in Nature Reviews Gastroenterology & Hepatology 23.57
Yuan Zhai33
Estimated H-index: 33
,
Henrik Petrowsky26
Estimated H-index: 26
+ 2 AuthorsJerzy W. Kupiec-Weglinski57
Estimated H-index: 57
Ischaemia–reperfusion injury (IRI) in the liver is a major complication of transplantation. This Review outlines our current understanding of the cellular and molecular mechanisms that underlie liver IRI and summarizes the latest progress in large animal models and clinical trials of liver IRI.
220 Citations Source Cite
Published on Jan 1, 2013in Journal of Craniofacial Surgery 0.79
Edward J. Caterson20
Estimated H-index: 20
,
Joseph Lopez14
Estimated H-index: 14
+ 2 AuthorsStefan G. Tullius44
Estimated H-index: 44
16 Citations Source Cite
Published on Dec 1, 2012in Immunity 21.52
Melanie Greter32
Estimated H-index: 32
(UZH: University of Zurich),
Iva Lelios5
Estimated H-index: 5
(UZH: University of Zurich)
+ 8 AuthorsMiriam Merad76
Estimated H-index: 76
(ISMMS: Icahn School of Medicine at Mount Sinai)
Colony stimulating factor-1 (Csf-1) receptor and its ligand Csf-1 control macrophage development, maintenance, and function. The development of both Langerhans cells (LCs) and microglia is highly dependent on Csf-1 receptor signaling but independent of Csf-1. Here we show that in both mice and humans, interleukin-34 (IL-34), an alternative ligand for Csf-1 receptor, is produced by keratinocytes in the epidermis and by neurons in the brain. Mice lacking IL-34 displayed a marked reduction of LCs a...
256 Citations Source Cite
Published on Nov 1, 2012in Immunity 21.52
Kristin Seré11
Estimated H-index: 11
(RWTH Aachen University),
Jea-Hyun Baek3
Estimated H-index: 3
(RWTH Aachen University)
+ 5 AuthorsThomas Hieronymus18
Estimated H-index: 18
(RWTH Aachen University)
Langerhans cells (LCs), the dendritic cells (DCs) in skin epidermis, possess an exceptional life cycle and developmental origin. Here we identified two types of LCs, short-term and long-term LCs, which transiently or stably reconstitute the LC compartment, respectively. Short-term LCs developed from Gr-1hi monocytes under inflammatory conditions and occurred independently of the transcription factor Id2. Long-term LCs arose from bone marrow in steady state and were critically dependent on Id2. S...
109 Citations Source Cite
Published on May 1, 2012in Journal of Clinical Investigation 12.28
Mercedes Gomez de Agüero3
Estimated H-index: 3
,
Marc Vocanson18
Estimated H-index: 18
+ 6 AuthorsBertrand Dubois29
Estimated H-index: 29
Allergic contact dermatitis is the most frequent occupational disease in industrialized countries. It is caused by CD8+ T cell–mediated contact hypersensitivity (CHS) reactions triggered at the site of contact by a variety of chemicals, also known as weak haptens, present in fragrances, dyes, metals, preservatives, and drugs. Despite the myriad of potentially allergenic substances that can penetrate the skin, sensitization is relatively rare and immune tolerance to the substance is often induced...
106 Citations Source Cite
Published on May 1, 2012in Immunity 21.52
Julien Seneschal2
Estimated H-index: 2
(University of Bordeaux),
Rachael A. Clark39
Estimated H-index: 39
(Brigham and Women's Hospital)
+ 2 AuthorsThomas S. Kupper76
Estimated H-index: 76
(Brigham and Women's Hospital)
Summary Recent studies have demonstrated that the skin of a normal adult human contains 10–20 billion resident memory T cells, including various helper, cytotoxic, and regulatory T cell subsets, that are poised to respond to environmental antigens. Using only autologous human tissues, we report that both in vitro and in vivo, resting epidermal Langerhan cells (LCs) selectively and specifically induced the activation and proliferation of skin resident regulatory T (Treg) cells, a minor subset of ...
242 Citations Source Cite
Published on Mar 1, 2012in Transplantation 4.59
Paul J. Chestovich2
Estimated H-index: 2
,
Yoichiro Uchida17
Estimated H-index: 17
+ 5 AuthorsJerzy W. Kupiec-Weglinski57
Estimated H-index: 57
Background. Ischemia-reperfusion injury (IRI) is common in general surgery and organ transplantation, and in the case of liver, it triggers proinflammatory innate immune cascade and hepatic necrosis, leading to increased incidence of early and late organ rejection. Interleukin (IL)-22, an inducible cytokine of T-cell origin and a member of the IL-10 superfamily, acts on target tissues through IL-22 receptor (IL-22R1). Methods. Partial hepatic warm ischemia was induced in C57Bl/6 wild-type (WT) a...
40 Citations Source Cite
Published on Feb 1, 2012in The FASEB Journal 5.39
Conrad A. Farrar17
Estimated H-index: 17
,
Brian Keogh15
Estimated H-index: 15
(Trinity College, Dublin)
+ 4 AuthorsSteven H. Sacks47
Estimated H-index: 47
Toll-like receptors (TLRs) are important molecules involved in the activation of innate and subsequent development of adaptive immunity. TLRs are ligated by exogenous ligands from pathogens and by endogenous ligands released in inflammatory diseases. Activation of TLR leads to activation of NF-κB and release of proinflammatory cytokines, such as IL-6 and TNF-α. TLRs play an important role in the pathogenesis of renal diseases. Increased expression of TLRs have been associated with ischemic kidne...
57 Citations Source Cite
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