FOXD1 expression is associated with poor prognosis in non-small cell lung cancer.

Clinical microarray datasets were analyzed to search for new therapeutic targets and prognostic markers of non-small cell lung cancer (NSCLC).Microarray datasets from 90 lung cancer specimens, were analyzed with focus on the FOXD1 gene. Levels of FOXD1 mRNA were assessed in lung cancer cell lines and these levels were correlated with survival.FOXD1-knockdown led to suppression of cell proliferation. Moreover, patients with high FOXD1 expression...