Increased chromosomal radiosensitivity in asymptomatic carriers of a heterozygous BRCA1 mutation
Abstract
Breast cancer risk increases drastically in individuals carrying a germline BRCA1 mutation. The exposure to ionizing radiation for diagnostic or therapeutic purposes of BRCA1 mutation carriers is counterintuitive, since BRCA1 is active in the DNA damage response pathway. The aim of this study was to investigate whether healthy BRCA1 mutations carriers demonstrate an increased radiosensitivity compared with healthy individuals. We defined a novel...
Paper Details
Title
Increased chromosomal radiosensitivity in asymptomatic carriers of a heterozygous BRCA1 mutation
Published Date
May 17, 2016
Journal
Volume
18
Issue
1
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