Proteomic profiling of small-molecule inhibitors reveals dispensability of MTH1 for cancer cell survival.
Abstract
Since recent publications suggested that the survival of cancer cells depends on MTH1 to avoid incorporation of oxidized nucleotides into the cellular DNA, MTH1 has attracted attention as a potential cancer therapeutic target. In this study, we identified new purine-based MTH1 inhibitors by chemical array screening. However, although the MTH1 inhibitors identified in this study targeted cellular MTH1, they exhibited only weak cytotoxicity...
Paper Details
Title
Proteomic profiling of small-molecule inhibitors reveals dispensability of MTH1 for cancer cell survival.
Published Date
May 23, 2016
Journal
Volume
6
Issue
1
Pages
26521 - 26521
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Notes
History