Thiolupinine and some derivatives of pharmacological interest.
Abstract
The (quinolizidin-1 alpha-yl)methanthiol (thiolupinine) was prepared and, utilizing the thiol group reactivity, several S-substituted derivatives were obtained among which was a group of 3-[(lupinylthio)methyl]indoles. Eight of the prepared compounds were subjected to a broad pharmacological screening that evidentiated for many of them good level of the following activities in vivo and in vitro: antiarrhythmic, local anesthetic, negative...
Paper Details
Title
Thiolupinine and some derivatives of pharmacological interest.
Published Date
Aug 1, 1993
Journal
Volume
48
Issue
8
Pages
1021 - 1049
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History