Formation of Chromosomal Domains by Loop Extrusion
Abstract
Topologically associating domains (TADs) are fundamental structural and functional building blocks of human interphase chromosomes, yet the mechanisms of TAD formation remain unclear. Here, we propose that loop extrusion underlies TAD formation. In this process, cis-acting loop-extruding factors, likely cohesins, form progressively larger loops but stall at TAD boundaries due to interactions with boundary proteins, including CTCF. Using polymer...
Paper Details
Title
Formation of Chromosomal Domains by Loop Extrusion
Published Date
May 1, 2016
Journal
Volume
15
Issue
9
Pages
2038 - 2049
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