CRISPR Repair Reveals Causative Mutation in a Preclinical Model of Retinitis Pigmentosa
Abstract
Massive parallel sequencing enables identification of numerous genetic variants in mutant organisms, but determining pathogenicity of any one mutation can be daunting. The most commonly studied preclinical model of retinitis pigmentosa called the rodless (rd1) mouse is homozygous for two mutations: a nonsense point mutation (Y347X) and an intronic insertion of a leukemia virus (Xmv-28). Distinguishing which mutation causes retinal degeneration...
Paper Details
Title
CRISPR Repair Reveals Causative Mutation in a Preclinical Model of Retinitis Pigmentosa
Published Date
Aug 1, 2016
Journal
Volume
24
Issue
8
Pages
1388 - 1394
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