HuR and GRSF1 modulate the nuclear export and mitochondrial localization of the lncRNA RMRP

Volume: 30, Issue: 10, Pages: 1224 - 1239
Published: May 15, 2016
Abstract
Some mitochondrial long noncoding RNAs (lncRNAs) are encoded by nuclear DNA, but the mechanisms that mediate their transport to mitochondria are poorly characterized. Using affinity RNA pull-down followed by mass spectrometry analysis, we found two RNA-binding proteins (RBPs), HuR (human antigen R) and GRSF1 (G-rich RNA sequence-binding factor 1), that associated with the nuclear DNA-encoded lncRNA RMRP and mobilized it to mitochondria. In...
Paper Details
Title
HuR and GRSF1 modulate the nuclear export and mitochondrial localization of the lncRNA RMRP
Published Date
May 15, 2016
Volume
30
Issue
10
Pages
1224 - 1239
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