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The contribution of different adipose tissue depots to plasma plasminogen activator inhibitor-1 (PAI-1) levels.

Published on Nov 1, 2016in Blood Reviews6.125
· DOI :10.1016/j.blre.2016.05.002
Sunelle A. Barnard3
Estimated H-index: 3
(NWU: North-West University),
Marlien Pieters16
Estimated H-index: 16
(NWU: North-West University),
Zelda de Lange6
Estimated H-index: 6
(NWU: North-West University)
Abstract
Increased plasma plasminogen activator inhibitor-1 (PAI-1) level is considered a mechanistic pathway through which obesity contributes to increased cardiovascular disease risk. Abdominal adipose tissue specifically, is a major PAI-1 source with visceral adipose tissue (VAT), an ectopic fat depot, generally considered to produce more PAI-1 than subcutaneous adipose tissue. However, this does not necessarily lead to increased plasma PAI-1 levels. This review provides an overview of studies investigating the association between body fat distribution and plasma PAI-1 levels. It discusses factors that influence this relationship and also considers the contribution of other tissue to plasma PAI-1 levels, placing the relative contribution of adipose tissue into perspective. In conclusion, the relationship between VAT and plasma PAI-1 levels is not fixed but can be modulated by a number of factors such as the size of the subcutaneous adipose tissue depot, ethnicity, possibly genetics and other obesity-related metabolic abnormalities.
  • References (104)
  • Citations (10)
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#1Geoffrey H. Tofler (RNSH: Royal North Shore Hospital)H-Index: 63
#2Joseph M. Massaro (BU: Boston University)H-Index: 89
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Abstract Introduction Although plasminogen activator inhibitor (PAI-1) plays a key regulatory role in fibrinolysis, it has not been clearly shown to independently predict cardiovascular disease (CVD) among individuals without prior CVD. We investigated, in the Framingham Heart Study offspring cohort, whether PAI-1 predicted CVD risk among individuals without prior CVD. Methods Plasma PAI-1 antigen and tissue plasminogen activator (TPA) antigen were measured in 3203 subjects without prior CVD bet...
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#1Philna Eksteen (NWU: North-West University)H-Index: 1
#2Marlien Pieters (NWU: North-West University)H-Index: 16
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SANPAD (South Africa - Netherlands Research Programme on Alternatives in Development); South African National Research Foundation (NRF GUN numbers 2069139, FA2006040700010 and FA2006041100003. South African Medical Research Council; the North-West University, Potchefstroom, South Africa; and the PHRI (Population Health Research Institute), ON, Canada
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Abstract Plasminogen activator inhibitor-1 (PAI-1) is a member of the serine protease inhibitor (serpin) superfamily, which inactivates tissue plasminogen activator (tPA); therefore, increased level of PAI-1 antigen counteracts the anticoagulant effect of tPA and facilitates the fibrin clot formation. Plasma PAI-1 antigen and activity levels are associated with increased body mass index and with features of the insulin resistance syndrome like obesity and diabetes. Visceral adipose tissue produc...
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