Binding of Folic Acid Induces Specific Self-Aggregation of Lactoferrin: Thermodynamic Characterization

Volume: 31, Issue: 45, Pages: 12481 - 12488
Published: Nov 3, 2015
Abstract
In the study presented here, we investigated the interaction at pH 5.5 between folic acid (FA) and lactoferrin (LF), a positively charged protein. We found a binding constant Ka of 10(5) M(-1) and a high stoichiometry of 10 mol of FA/mol of LF. The size and charge of the complexes formed evolved during titration experiments. Increasing the ionic strength to 50 mM completely abolished the isothermal titration calorimetry (ITC) signal, suggesting...
Paper Details
Title
Binding of Folic Acid Induces Specific Self-Aggregation of Lactoferrin: Thermodynamic Characterization
Published Date
Nov 3, 2015
Journal
Volume
31
Issue
45
Pages
12481 - 12488
Citation AnalysisPro
  • Scinapse’s Top 10 Citation Journals & Affiliations graph reveals the quality and authenticity of citations received by a paper.
  • Discover whether citations have been inflated due to self-citations, or if citations include institutional bias.