Breaking Cryo-EM Resolution Barriers to Facilitate Drug Discovery
Abstract
Recent advances in single-particle cryoelecton microscopy (cryo-EM) are enabling generation of numerous near-atomic resolution structures for well-ordered protein complexes with sizes ≥ ∼200 kDa. Whether cryo-EM methods are equally useful for high-resolution structural analysis of smaller, dynamic protein complexes such as those involved in cellular metabolism remains an important question. Here, we present 3.8 Å resolution cryo-EM structures of...
Paper Details
Title
Breaking Cryo-EM Resolution Barriers to Facilitate Drug Discovery
Published Date
Jun 1, 2016
Journal
Volume
165
Issue
7
Pages
1698 - 1707
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