Review of succinate dehydrogenase-deficient renal cell carcinoma with focus on clinical and pathobiological aspects
Abstract
Succinate dehydrogenase (SDH)-deficient renal cell carcinoma (RCC) was first identified in 2004 and has been integrated into the 2016 WHO classification of RCC. Succinate dehydrogenase (SDH) is an enzyme complex composed of four protein subunits (SDHA, SDHB, SDHC and SDHD). The tumor which presents this enzyme mutation accounts for 0.05 to 0.2% of all renal carcinomas. Multiple tumors may occur in approximately 30% of affected patients....
Paper Details
Title
Review of succinate dehydrogenase-deficient renal cell carcinoma with focus on clinical and pathobiological aspects
Published Date
Jan 1, 2016
Journal
Volume
1
Pages
3 - 7
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