Leukotriene E 4 elicits respiratory epithelial cell mucin release through the G-protein–coupled receptor, GPR99
Volume: 113, Issue: 22, Pages: 6242 - 6247
Published: May 16, 2016
Abstract
Significance Leukotriene E 4 (LTE 4 ), a lipid mediator detected in asthma exacerbations triggered by allergen, viruses, and aspirin, elicits airflow obstruction and lung inflammation in asthmatics. GPR99 is the recently identified high-affinity receptor for LTE 4 and is resistant to blockade by commercially available cysteinyl leukotriene (cysLT) receptor antagonists. Here we find that GPR99 is expressed in respiratory epithelial cells and...
Paper Details
Title
Leukotriene E 4 elicits respiratory epithelial cell mucin release through the G-protein–coupled receptor, GPR99
Published Date
May 16, 2016
Volume
113
Issue
22
Pages
6242 - 6247
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