Ictal lack of binding to brain parenchyma suggests integrity of the blood–brain barrier for¹¹C-dihydroergotamine during glyceryl trinitrate-induced migraine

See Dreier (doi: 10.1093/aww112 ) for a scientific commentary on this article. For many decades a breakdown of the blood–brain barrier has been postulated to occur in migraine. Hypothetically this would facilitate access of medications, such as dihydroergotamine or triptans, to the brain despite physical properties otherwise restricting their entry. We studied the permeability of the blood–brain barrier in six migraineurs and six control...