Abstract C3: Activating necroptosis in acute myeloid leukemia through inhibition of PKC, calmodulin, and HOX/PBX dimerization

The molecular mechanisms underlying the pathogenesis of acute myeloid leukemia (AML) have been extensively studied, and are known to involve members of the HOX family of transcription factors, both as partners in chimeric fusion proteins, and also in their wild type form. However, the role of HOX proteins in the survival of AML cells has proved difficult to assess as many have redundant functions, which makes a conventional knock down experiment...