MCT4 as a potential therapeutic target for metastatic gastric cancer with peritoneal carcinomatosis
Abstract
Monocarboxylate transporters (MCTs) play a major role in up-regulation of glycolysis and adaptation to acidosis. However, the role of MCTs in gastric cancer (GC) is not fully understood. We investigated the potential utilization of a new cancer therapy for GC. We characterized the expression patterns of the MCT isoforms 1, 2, and 4 and investigated the role of MCT in GC through in vitro and in vivo tests using siRNA targeting MCTs. In GC cell...
Paper Details
Title
MCT4 as a potential therapeutic target for metastatic gastric cancer with peritoneal carcinomatosis
Published Date
May 20, 2016
Journal
Volume
7
Issue
28
Pages
43492 - 43503
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History