mTORC2 in Thymic Epithelial Cells Controls Thymopoiesis and T Cell Development
Abstract
Thymic epithelial cells (TECs) play important roles in T cell generation. Mechanisms that control TEC development and function are still not well defined. The mammalian or mechanistic target of rapamycin complex (mTORC)2 signals to regulate cell survival, nutrient uptake, and metabolism. We report in the present study that mice with TEC-specific ablation of Rictor, a critical and unique adaptor molecule in mTORC2, display thymic atrophy, which...
Paper Details
Title
mTORC2 in Thymic Epithelial Cells Controls Thymopoiesis and T Cell Development
Published Date
Jul 1, 2016
Journal
Volume
197
Issue
1
Pages
141 - 150
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