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C-Reactive Protein and Procalcitonin as Predictors of Postoperative Inflammatory Complications After Pancreatic Surgery

Published on Aug 1, 2016in Journal of Gastrointestinal Surgery2.686
· DOI :10.1007/s11605-016-3171-6
Alessandro Giardino8
Estimated H-index: 8
,
Gaya Spolverato31
Estimated H-index: 31
+ 7 AuthorsGiovanni Butturini36
Estimated H-index: 36
Sources
Abstract
Background The association between postoperative inflammatory markers and risk of complications after pancreaticoduodenectomy (PD) is controversial. We sought to assess the diagnostic value of perioperative C-reactive protein (CRP) and procalcitonin (PCT) levels in the early identification of patients at risk for complications after PD.
  • References (35)
  • Citations (9)
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References35
Newest
#1Olivier FacyH-Index: 13
#2Brice PaquetteH-Index: 7
Last. Pablo Ortega-DeballonH-Index: 16
view all 10 authors...
Abstract Intra-abdominal infections are frequent and life-threatening complications after colorectal surgery. An early detection could diminish their clinical impact and permit safe early discharge. This study aimed to find the most accurate marker for the detection of postoperative intra-abdominal infection and the appropriate moment to measure it. A prospective, observational study was conducted in 3 centers. Consecutive patients undergoing elective colorectal surgery with anastomosis were inc...
46 CitationsSource
Last. Giovanni RamacciatoH-Index: 30
view all 11 authors...
Objectives:We designed a multicentric, observational study to test if Procalcitonin (PCT) might be an early and reliable marker of anastomotic leak (AL) after colorectal surgery (ClinicalTrials.govIdentifier:NCT01817647).Background:Procalcitonin is a biomarker used to monitor bacterial infections an
23 CitationsSource
#2David PetermannH-Index: 5
Last. Markus SchäferH-Index: 34
view all 4 authors...
Pancreatic surgery remains associated with important morbidity. Efforts are most commonly concentrated on decreasing postoperative morbidity, but early detection of patients at risk could be another valuable strategy. A simple prognostic score has recently been published. This study aimed to validate this score and discuss possible clinical implications.From 2000 to 2012, 245 patients underwent a pancreaticoduodenectomy. Complications were graded according to the Dindo-Clavien Classification. Th...
11 CitationsSource
#1A Vallance (Leeds Teaching Hospitals NHS Trust)H-Index: 7
#2Alastair L. Young (Leeds Teaching Hospitals NHS Trust)H-Index: 11
Last. Andrew M Smith (Leeds Teaching Hospitals NHS Trust)H-Index: 9
view all 5 authors...
Abstract Background A post‐operative pancreatic fistula (POPF) is a major cause of morbidity and mortality after a pancreaticoduodenectomy (PD). This systematic review aimed to identify all scoring systems to predict POPF after a PD, consider their clinical applicability and assess the study quality. Method An electronic search was performed of Medline (1946–2014) and EMBASE (1996–2014) databases. Results were screened according to Preferred Reporting Items for Systematic Reviews and Meta‐Analys...
26 CitationsSource
2 CitationsSource
#1Alessandro Paniccia (Anschutz Medical Campus)H-Index: 10
#2Patrick W. Hosokawa (CU: University of Colorado Boulder)H-Index: 18
Last. Csaba Gajdos (Anschutz Medical Campus)H-Index: 25
view all 7 authors...
Importance To our knowledge, this study reports on the largest cohort of long-term survivors (LTSs) (≥10 years) following a diagnosis of pancreatic ductal adenocarcinoma (PADC) and identifies the characteristics associated with LTS. Objective To determine patient, tumor, surgical, and sociodemographic characteristics associated with LTS. Design, Setting, and Participants A nationwide retrospective cohort study of patients with invasive PADC ( International Classification of Diseases for Oncology...
46 CitationsSource
#1Ji-Ye ChenH-Index: 3
#2Jian FengH-Index: 2
Last. Yong-Liang ChenH-Index: 3
view all 6 authors...
AIM: To establish a scoring system to predict clinically relevant postoperative pancreatic fistula (CR-POPF) after pancreaticoduodenectomy (PD). METHODS: The clinical records of 921 consecutive patients who underwent PD between 2008 and 2013 were reviewed retrospectively. Postoperative pancreatic fistula (POPF) was defined and classified by the international study group of pancreatic fistula (ISGPF). We used a logistic regression model to determine the independent risk factors of CR-POPF and dev...
22 CitationsSource
We reviewed the use of the levels of C-reactive protein, lactate and procalcitonin and/or the Sequential Organ Failure Assessment score to determine their diagnostic accuracy for predicting surgical complications in critically ill general post-surgery patients. Included were all studies published in PubMed from inception to July 2013 that met the following inclusion criteria: evaluation of the above parameters, describing their diagnostic accuracy and the risk stratification for surgical complic...
5 CitationsSource
#1Shun-Jun Fu (Guangzhou University of Chinese Medicine)H-Index: 9
#2Shun-Li Shen (SYSU: Sun Yat-sen University)H-Index: 10
Last. Bao-Gang Peng (SYSU: Sun Yat-sen University)H-Index: 12
view all 8 authors...
Background Pancreatic fistula (PF) remains the most challenging complication after pancreaticoduodenectomy (PD). The purpose of this study was to identify the risk factors of PF and delineate its impact on patient outcomes.
26 CitationsSource
#1Sandra H. Hoeboer (EUR: Erasmus University Rotterdam)H-Index: 3
#2A. B. Johan Groeneveld (EUR: Erasmus University Rotterdam)H-Index: 39
Last. Jasper van Bommel (EUR: Erasmus University Rotterdam)H-Index: 27
view all 6 authors...
Background Elective esophagectomy with gastric tube reconstruction carries a high risk for complications. Early and accurate diagnosis could improve patient management. Increased C-reactive protein (CRP) levels may be associated with any, surgical or infectious, complication and procalcitonin (PCT) specifically with infectious complications.
21 CitationsSource
Cited By9
Newest
BACKGROUND: To investigate the early prediction value of procalcitonin (PCT) in pancreatic fistula (POPF) after pancreatoduodenectomy (PD). METHOD: Retrospective analysis of clinical data of 67 patients undergoing pancreaticoduodenectomy (PD) and 19 patients undergoing distalpancreatectomy (DP) were performed in the Department of Hepatobiliary Surgery, Leshan People's Hospital from January 2017 to December 2018. All patients were divided into POPF group and non-POPF group depending on the presen...
Source
Abstract Backround C-reactive protein (CRP) and procalcitonin (PCT) have shown to be reliable predictors of inflammatory complications and anastomotic leak after colorectal surgery. Their predictive value after partial pancreaticoduodenectomy (PD) remains unclear. Materials and methods All consecutive pancreaticoduodenectomies (2009–2018) at our hospital were included. Drain amylase was evaluated on postoperative day (POD) 1, serum CRP and PCT were evaluated on POD 1–3. Receiver-operating charac...
1 CitationsSource
#1Hiroya Iida (Shiga University of Medical Science)H-Index: 10
#2Hiromitsu Maehira (Shiga University of Medical Science)H-Index: 2
Last. Masajitani (Shiga University of Medical Science)H-Index: 28
view all 4 authors...
Procalcitonin (PCT) is an early predictor of bacterial infection. We reviewed the literature and analyzed data on our own patients to assess the value of PCT as a predictor of infectious complications after pancreaticoduodenectomy (PD). The relevant literature published up until November 30, 2018, was reviewed, with no publication date restrictions. Letters to the editor and studies lacking necessary data were excluded. We also reviewed, retrospectively, the medical records of 77 patients who un...
3 CitationsSource
#1Yuichiro Uchida (Kyoto University)H-Index: 2
#2Toshihiko Masui (Kyoto University)H-Index: 20
Last. Shinji Uemoto (Kyoto University)H-Index: 66
view all 9 authors...
Abstract Background Recent management after pancreatoduodenectomy recommends either omission of prophylactic drainage or early removal. This potentially makes the diagnosis of postoperative pancreatic fistula (POPF) difficult because the diagnosis is based on the amylase value of drain effluent. The aim of this study was to determine if severe POPF could be predicted independent of drainage information. Methods Records of consecutive patients who underwent pancreatoduodenectomy between 2012 and ...
2 CitationsSource
Abstract Background Prediction of complications after pancreatoduodenectomy (PD) remains of interest. Blood parameters and biomarkers during first and second postoperative days (POD1, POD2) may be early indicators of complications. Methods This case-control study included 50 patients. Baseline, POD1 and POD2 values of leukocytes, neutrophils, lymphocytes, platelets, hemoglobin, C-reactive protein (CRP), procalcitonin and arterial lactate were compared between individuals presenting Clavien ≥ III...
Source
#1F. Jasmijn Smits (UU: Utrecht University)H-Index: 4
#2Quintus Molenaar (UU: Utrecht University)H-Index: 22
Last. Hjalmar C. van Santvoort (UU: Utrecht University)H-Index: 38
view all 7 authors...
Abstract Background Early recognition of postoperative pancreatic fistula might decrease the risk of subsequent life threatening complications. The aim of this review was to systematically evaluate the accuracy of postoperative clinical, biochemical and radiologic variables for early recognition of clinically relevant postoperative pancreatic fistula. Methods A systematic literature search was performed up to August 2018. Clinical studies reporting on the association between postoperative variab...
2 CitationsSource
#1Christoph Späth (North Shore Hospital)
#2Sanket Srinivasa (North Shore Hospital)H-Index: 17
Last. Jonathan B. Koea (North Shore Hospital)H-Index: 20
view all 6 authors...
BACKGROUND: This study was undertaken to assess the value of C-reactive protein (CRP) in predicting infective complications after elective upper gastrointestinal surgery. METHODS: Demographic data, clinical outcomes and serial CRPs preoperatively to post-operative day (POD) 7 were collected for patients undergoing pancreatectomy, hepatectomy and oesophago-gastrectomy between 2005 and 2016. Areas under the curve (AUC) were used to evaluate diagnostic accuracy per day of measurement. RESULTS: Of t...
Source
#1Yuto AokiH-Index: 1
#2Nobuhiko TaniaiH-Index: 20
Last. Eiji UchidaH-Index: 27
view all 10 authors...
BACKGROUND: Relatively high mortality and morbidity rates are reported after liver resection (LR). However, the early predictors of complications after LR are not clear. This study was performed to clarify the usefulness of procalcitonin (PCT) for the early prediction of complications after elective LR. METHODS: This observational study included 72 consecutive patients who underwent elective LR from December 2015 to March 2017. Patients were categorized into two groups: those with and without po...
1 CitationsSource
#1Simon McCluney (Barts Health NHS Trust)H-Index: 2
#2Alexandros A. Giakoustidis (Barts Health NHS Trust)H-Index: 1
Last. HemantMKocher (Barts Health NHS Trust)H-Index: 31
view all 9 authors...
BACKGROUND AND OBJECTIVES: Approximately 30-50% of patients with colorectal cancer develop liver metastasis for which liver resection is the only hope for potential cure. However, hepatic resection is associated with considerable morbidity. The aim was to detect early complications by utilising the neutrophil: lymphocyte ratio (NLR). METHODS: We performed a retrospective cohort study of patients undergoing hepatic resection at a single institution between 2008 and 2016. Baseline demographics and...
3 CitationsSource
#1Théophile Guilbaud (AMU: Aix-Marseille University)H-Index: 3
#2David Jérémie Birnbaum (AMU: Aix-Marseille University)H-Index: 5
Last. Vincent Moutardier (AMU: Aix-Marseille University)H-Index: 30
view all 8 authors...
Background Postoperative pancreatic fistula and pancreas-specific complications have a significant influence on patient management and outcomes after pancreatoduodenectomy. The aim of the study was to assess the value of serum C-reactive protein on the postoperative day 1 as early predictor of pancreatic fistula and pancreas-specific complications.
1 CitationsSource