Study on in vitro cytotoxicity and in vivo antitumor effect of liposomes containing topotecan hydrochloride

Abstract
Objective To study the cytotoxic effect in vitro and antitumor action of conventional liposome(Plain-L)or PEG-modified liposome(PEG-L)containing topotecan hydrochloride.Methods The in vitro cytotoxic effect of Plain-L and PEG-L against ovarian carcinoma A2780 and human colon carcinoma HCT-8 cells were studied by MTT assay method.The antitumor effect studies in vivo of Plain-L and PEG-L were performed in murine heptocarcinoma H_(22) tumor-bearing...
Paper Details
Title
Study on in vitro cytotoxicity and in vivo antitumor effect of liposomes containing topotecan hydrochloride
Published Date
Jan 1, 2006
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