Syntheses and Anticancer Activities of Glycine Derivatives of Chrysin

In order to obtain novel lead compounds with high efficacy,low toxicity and minimum of side effects,using chrysin(5,7-dihydroxyflavone) with very broad biological activities as a starting material,four intermediates 7-O-carboxyalkylation chrysin derivatives(6—9) were synthesized by halogenation and hydrolysis.Four glycine methyl ester derivatives containing chrysin(12—15) were synthesized when the four intermediates above condensated with...