Broadly Neutralizing Antibodies to HIV and Their Role in Vaccine Design
Abstract
HIV employs multiple means to evade the humoral immune response, particularly the elicitation of and recognition by broadly neutralizing antibodies (bnAbs). Such antibodies can act antivirally against a wide spectrum of viruses by targeting relatively conserved regions on the surface HIV envelope trimer spike. Elicitation of and recognition by bnAbs are hindered by the arrangement of spikes on virions and the relatively difficult access to bnAb...
Paper Details
Title
Broadly Neutralizing Antibodies to HIV and Their Role in Vaccine Design
Published Date
May 20, 2016
Journal
Volume
34
Issue
1
Pages
635 - 659
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